Liquid-phase peptide synthesis (LPPS), on the other hand, is like the seasoned artist of the peptide synthesis world—flexible, capable, and a bit traditional. LPPS offers advantages in the synthesis of long or complex peptides, where precision and the ability to tweak conditions are paramount. Though less commonly used than SPPS, LPPS remains a valuable tool in the peptide chemist’s arsenal, especially for crafting peptides with intricate structures.
